Poloxamer 188 as surfactant in biological formulations – An

polo188Structure of Poloxamer 188, with two hydrophilic ends and a hydrophobic core in the middle. Currently, available literature depicts that P188 has a half-life of 18 hours after injection inVariability in poloxamer 188 (P188) raw material, which is routinely used in cell culture media to protect cells from hydrodynamic forces, plays an important role in the process performance.